Medchemexpress LLC IKK 16 hydrochloride | 1186195-62-9 | 99.95% | 520.09 | 10 MM * 1 ML

Supplier:  Medchemexpress LLC HY13687A10MM/1ML

IKK 16 hydrochloride is an orally active IKK inhibitor, also acting as a pan-PKD and ABCB1 inhibitor. It protects against LPS-induced multiple organ dysfunction, restores renal function, alleviates fibrosis in acute kidney injury, and attenuates cardiac dysfunction by inhibiting the NF-κB pathway.

• Inhibits IκB degradation and TNFα-stimulated expression of adhesion molecules.
• Acts as an ATP-competitive inhibitor of PKD1 and inhibits PKCα and PKCδ.
• Protects against LPS-induced multiple organ dysfunction.
• Improves renal function and prevents fibrosis after acute kidney injury.
• Suppresses systemic TNFα levels and inhibits neutrophil extravasation.
• Reduces cardiac dysfunction and NF-κB pathway activation in sepsis models.

Catalog No. 50-003-48535