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Eurofins Discoverx IKKε, active, 10 µg. (14-926)
Supplier: Eurofins Discoverx 14926
N-terminal FLAG, GST-tagged recombinant, human IKKε full length. IKBKE is a non-canonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death. For detailed product information, visit www.discoverx.com/proteins.
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