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Medchemexpress LLC Ikky nbd inhibitory peptide tfa | 98.2% | 3807.32 | 5 MG
SDP

Supplier:  Medchemexpress LLC HYP1847A5MG

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IKKγ NBD Inhibitory Peptide TFA is a highly specific NF-κB inhibitor. It functions by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) and IKKα and IKKβ, thereby blocking TNF-α-induced NF-kB activation. This peptide can significantly suppress inflammation and ameliorate cerebral ischemia-induced neurological deficits.

  • Prevents p65 phosphorylation in BT-474 cells.
  • Slightly inhibits BT-474 cell viability while markedly enhancing Doxorubicin's effects.
  • Exhibits neuroprotective effect with reduction in DNA fragmentation in a rat model.
  • Reduces striatal IL-1b level and microglial OX-42 staining.
  • Protects the blood-brain barrier from ischemic insult.

Catalog No. 50-004-22586


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