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Genscript Corporation Antibody Protein Proteins Proteins 50 UG 1/EA
Supplier: Genscript Corporation Z0316950
IL-1 Receptor Antagonist also known as IL-1RA ICIL-1RA IRAP and IL-1RN is a member of the interleukin 1 cytokine family. It is expressed by monocytes neutrophils macrophages epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis rheumatoid arthritis and chronic myelogenous leukemia.
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