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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z031711
Interleukin-10 (IL-10) initially known as Cytokine Synthesis Inhibitory Factor (CSIF) belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI. It is produced by many immune cells such as T-cells macrophages mast cells and dendritic cells. It is usually secreted as a homodimer and upon binding to its receptor inhibits the synthesis of a number of cytokines including IFN-gamma IL-2 IL-3 TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays the ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however stimulatory effects such as stimulation of B cell maturation and antibody production are also reported.
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