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Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | 99.0% | C27H34N6O2 | 50 MG
SDP

Catalog No. 5000354793
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IL-17 modulator 4 is a proagent of IL-17 modulator 1, an orally active and highly efficacious IL-17 modulator. This modulator stabilizes the conformation of IL-17A by binding to its central pocket, preventing effective binding to the IL-17RA receptor and inhibiting the IL-17A-mediated signaling pathway. It shows promise for research into IL-17A mediated diseases.

  • Modulator for IL-17A protein-protein interaction
  • Inhibits glycosylated IL-17A and TNFα costimulated IL-8 secretion in HEKa cells with an EC50 of 14 nM
  • Exhibits good pharmacokinetic properties in rat models with low clearance and good oral bioavailability
  • Suitable for research of IL-17A mediated diseases, including inflammation and autoimmune conditions

Catalog No. 50-003-54793 Supplier Medchemexpress LLC Supplier No. HY14169250MG
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IL-17 modulator 4 is a proagent of IL-17 modulator 1, an orally active and highly efficacious IL-17 modulator. This modulator stabilizes the conformation of IL-17A by binding to its central pocket, preventing effective binding to the IL-17RA receptor and inhibiting the IL-17A-mediated signaling pathway. It shows promise for research into IL-17A mediated diseases.

  • Modulator for IL-17A protein-protein interaction
  • Inhibits glycosylated IL-17A and TNFα costimulated IL-8 secretion in HEKa cells with an EC50 of 14 nM
  • Exhibits good pharmacokinetic properties in rat models with low clearance and good oral bioavailability
  • Suitable for research of IL-17A mediated diseases, including inflammation and autoimmune conditions

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