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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA
Supplier: Genscript Corporation Z0322810
Interleukin-17A (IL-17A) also known as CTLA-8 and IL-17 is a proinflammatory cytokine belonging to the IL-17 family. It is secreted by Th17 cells gamma/delta T cells NK cells and neutrophils. IL-17A signals through IL-17 receptor A in a complex with receptor C or D to regulate NF-kappaB and MAP kinase activities. IL-17A plays important roles in the anti-microbial response and chronic inflammation. It stimulates the production of IL-6 IL-8 and G-CSF in epithelial and endothelial cells and induces the expression of ICAM-1 in fibroblasts. Clinically IL-17A has been associated with inflammatory diseases such as rheumatoid arthritis psoriasis and multiple sclerosis.
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