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AdipoGen anti-IL-1alpha (mouse), mAb (Bamboo-1) (100 µg)
Supplier: AdipoGen AG20B0050C100
Monoclonal Antibody. Recognizes mouse IL-1alpha. Isotype: Mouse IgG. Clone: Bamboo-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. IL-1alpha and IL-1beta lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. Passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
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