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AdipoGen IL-1alpha (mouse) Matched Pair Detection Set (1 Set)
Supplier: AdipoGen AG46B0004KI01
Matched Pair Detection Set. Detects mouse IL-1alpha. Does not detect human IL-1alpha or mouse IL-1beta. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 2000pg/ml. Sensitivity: 10pg/ml. IL-1alpha lacks a signal peptide and is secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
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