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AdipoGen IL-2 Superkine FcH9T
Supplier: AdipoGen AG40B0219C010
Recombinant Protein. The extracellular domain of human IL-2 aa 21-153 mutant H9T containing the mutations of H9 L80F / R81D / L85V / I 86V / I92F and the new mutation Q126T is fused at the C-terminus to the Fc portion of human IgG2. Lyophilized. Contains PBS. Binds to human and mouse IL-2R. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
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