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AdipoGen IL-21 msFc LALA-PG-KIHh
Supplier: AdipoGen AG40B0250C050
Recombinant Protein. Mouse IL-21 aa 18-146 is fused at the C-terminus to the Fc portion of human IgG1 LALA-PG Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Endotoxin <0.02EU/µg protein LAL test.. Lyophilized. Contains PBS. IL-21 is a monomeric 15 kDa cytokine, identified as a multifunctional cytokine principally produced by follicular helper T Tfh, T helper 17 Th17 and natural killer NK cells, but also by CD8 T cells. As a receptor for IL-21, IL-21R, a class I cytokine heterodimeric receptor, shares a common cytokine receptor gamma chain with other cytokine families, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21 receptor IL-21R is heterodimeric composed of an alpha and ɣ-chain and physiologically expressed on immune cells T and B cells, macrophages, DCs, thymocytes and splenocytes.
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