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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z033151
Interleukin-22 (IL-22) is a member of a group of cytokines called the IL-10 family which include IL-10 IL-19 IL-20 IL-24 and IL-26. IL-22 shares use of the IL-10R2 in cell signaling with other members of this family IL-22 signals through a receptor system consisting of IL-10R-beta /CRF2-4 and IL-22R both of which are members of the class II cytokine-receptor family. IL-22 is produced by activated DCs and T cells and initiates an innate immune response against bacterial pathogens especially in epithelial cells such as those in the respiratory tract and gut. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can also be produced by Th17 cells which plays a likely role in the coordinated response of both adaptive and innate immune systems.
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