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AdipoGen IL-22 msFc ms non-lytic
Supplier: AdipoGen AG40B0231C050
Recombinant Protein. Extracellular domain of mouse IL-22 aa 34-179 is fused to the N-terminus of the mouse Fc IgG2a non-lytic mutant. Source W2. Lyophilized. Contains PBS. The IL-22 gene includes five exons and a 537 bp-long open reading frame that encodes for a 179 amino acid protein. IL-22 is a member of the IL-10 family of cytokines, which also includes IL-19, -20, -24, and -26, IL-28A/B, and IL-29 and IFNlambda. Mouse and human IL-22 share 79% homology. IL-22 is mainly produced by lymphocytes, such as T helper type 1 Th1, Th17, Th22, CD8 T cells, gammadelta T cells, natural killer cells, lymphoid tissue inducer cells, innate lymphoid type 3 ILC3 cells, and also by neutrophils. IL-22 has two heterodimeric transmembrane receptors, IL-22R1 and IL-10R2, which subsequently activate the JAK/STAT3, ERK and JNK pathways.
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