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AdipoGen IL-23 msFc LALA-PG-KIHh
Supplier: AdipoGen AG40B0248C050
Recombinant protein. IL-23A/p19 aa 22-196 mouseFc LALA-PG Knobs and IL-12B/p40 aa 23-335 mouseFc LALA-PG Holes form the IL-23 mouseFc LALA-PG-KIH human rec. using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source CHO cells. Produced using animal component-free medium. Lyophilized. Contains PBS Interleukin-12 IL-12 family members are heterodimer glycoproteins, composed of two covalently linked subunits, alpha and beta chains. The alpha-subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the beta-subunit includes IL-12p40 and Epstein-Barr virus-induced gene Ebi3. IL-12 members bind to cognate heterodimeric receptor chains expressed on T cells. This family includes IL-12, IL-23, IL-27, IL-35 and IL-39. IL-12 and IL-23 are predominantly proinflammatory cytokines that contribute key roles in the development of Th1 and Th17 cells, respectively.
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