Invitrogen™ Human IL-31 ELISA Kit

Catalog No.	Quantity
BMS20412TEN	10 x 96 Tests
BMS20412	96 Tests

Catalog No. BMS20412TEN Supplier Invitrogen™ Supplier No. BMS20412TEN

Description

ELISA

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

Specifications

• Accession Number: Q6EBC2
• Assay Range: 7.8-500 pg/mL
• Assay Sensitivity: 1.2 pg/mL
• Conjugate: HRP
• Immunoassay Kit Format: Sandwich ELISA Kit
• Product Type: ELISA
• Sample Type: Plasma, Serum, Supernatant
• Target Species: Human
• For Use With (Equipment): Absorbance Microplate Reader
• Gene Alias: 1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-311700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31;
• Gene ID (Entrez): 386653
• Gene Symbol: Il31
• Interassay CV: 3.3%
• Intraassay CV: 5.7%
• Kit Contents: Pre-coated 96 well plate, Standard (2 vials), Sample diluent, Biotinylated Detection Antibody, Assay buffer Concentrate, Wash buffer concentrate,SAV-HRP,TMB, Stop solution, Adhesive Plate Covers, Standard (2 vials), Sample diluent, Biotinylated Detection Antibody, Assay buffer Concentrate, Wash buffer concentrate, SAV-HRP, TMB, Stop solution, Adhesive Plate Covers
• Label or Dye: Biotin
• Protein: IL-31
• Protein Aliases: IL-31, Interleukin-31
• Quantity: 10 x 96 Tests
• Regulatory Status: RUO
• Sample Volume: Plasma 50 μL, Serum 50 μL, Supernatant 50 μL
• Shipping Condition: Wet Ice
• Storage Requirements: 2-8°C
• Target: IL-31
• Target Species Validated: Human
• Test Time: 1 hr 20 min
• Total Assay Time: 4 hr 30 min
• UniProt ID: Q6EBC2