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AdipoGen IL-33 h rec untagged
Supplier: AdipoGen AG40B00385010
Protein. Human IL-33 aa 112-270 is untagged. Source E. coli. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human ST2. Purity >95% SDS-PAGE. Interleukin-33 IL-33 HF-NEV IL-1F11, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 IL1R1 and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1MAPK3/ERK2MAPK1, p38MAPK14, and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
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