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AdipoGen anti-IL-33 (human), mAb (IL33305B) (50 µg)
Supplier: AdipoGen AG20A0041C050
Monoclonal Antibody. Recognizes human IL-33. Does not cross-react with mouse IL-33. Isotype: Mouse IgG2akappa. Clone: IL33305B. Applications: ELISA, FUNC (Blocking), IHC, IP, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
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