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AdipoGen IL-33 mouse pAb
Supplier: AdipoGen AG25A0047C100
Polyclonal Antibody. Recognizes mouse IL-33. Detects a band of ~18kDa by Western blot. Does not cross-react with human IL-33. Source Rabbit. Applications ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 IL-33 HF-NEV IL-1F11, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 IL1R1 and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1MAPK3/ERK2MAPK1, p38MAPK14, and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis.
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