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AdipoGen IL-33 ox-reshmonomer-KIH
Supplier: AdipoGen AG40B0233C050
Recombinant protein. Human IL-33 aa 112-270 with mutations C208S and C232S to protect IL-33 from oxidation is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS Interleukin-33 IL-33 HF-NEV IL-1F11, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 IL-1R1 and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 MAPK3 / ERK2 MAPK1, p38 MAPK14 and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis.
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