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AdipoGen IL-36gamma (human) ELISA Kit (96 wells)
Supplier: AdipoGen AG45B0008KI01
ELISA Assay. Detects natural and recombinant human IL-36gamma. Colorimetric assay. Sample Type: Cell Culture Supernatant, Serum. Range: 3.9 to 250pg/ml. Sensitivity: 3pg/ml. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) are members of the IL-1 cytokine family that bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. IL-36gamma is induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines and plays an important role in asthmatic pulmonary inflammation. IL-36gamma might be a potential biomarker of Inflammatory Bowel Disease and is highly expressed in inflamed skin from psoriasis patients and in Allergic Contact Dermatitis. IL-36gamma serum levels are enhanced and correlate to psoriasis severity and response to treatment with anti-TNF.
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