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AdipoGen anti-IL-36gamma (human), mAb (Jussy-1) (100 µg)
SDP

Supplier:  AdipoGen AG20B0072C100

Encompass_Preferred

Monoclonal Antibody. Recognizes human IL-36gamma. Isotype: Mouse IgG1kappa. Clone: Jussy-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells and keratinocyte proliferation. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.

Catalog No. 50-205-2985


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