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AdipoGen IL-37 hmonomericFc-KIHh
Supplier: AdipoGen AG40B02213010
Recombinant Protein. Human IL-37 aa 46-218 Delta5CysS-S and Y85A see reference A. Bujotzek, et al. 2022 is fused at the C-terminus to a Fc human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-37 IL-1F7 IL-1H4 is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells PBMCs and dendritic cells. IL-37 is a soluble and secreted cytokine of 218 residues that shares the beta-trefoil fold common to IL-1 family cytokines. But IL-37 is an atypical member of the IL-1 family of cytokines as it functions to inhibit many of the major pathways of innate and adaptive immunity and inflammation. It binds to the interleukin-18 receptor IL-18R and its co-receptor SIGIRR.
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