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AdipoGen IL-38 aa 3-152ms FLAG
SDP

Catalog No. 502562923
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Recombinant Protein. Mouse IL-38 IL-1F10 aa 3-152 is fused at the C-terminus to a FLAG -tag. Source E. coli. Lyophilized. Contains PBS 0.5% Trehalose 0.02% CHAPS. IL-38 IL-1F10 mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 20-152 binds to the receptor Interleukin-1 receptor accessory protein-like 1 IL1RAPL1 TIGIRR-2 at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.

Catalog No. 50-256-2923 Supplier AdipoGen Supplier No. AG40B01013010
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Recombinant Protein. Mouse IL-38 IL-1F10 aa 3-152 is fused at the C-terminus to a FLAG -tag. Source E. coli. Lyophilized. Contains PBS 0.5% Trehalose 0.02% CHAPS. IL-38 IL-1F10 mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 20-152 binds to the receptor Interleukin-1 receptor accessory protein-like 1 IL1RAPL1 TIGIRR-2 at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.

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