Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
AdipoGen IL-38 hrecHis MultiPack
Supplier: AdipoGen AG40A0191Y3010
Recombinant protein. Human IL-38 aa 1-152 is fused at the C-terminus to a His-tag. Source E. coli. Lyophilized. In 50mM TRIS-Cl, pH 8.0, containing 150mM NaCl. IL-38 IL-1F10 mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 20-152 binds to the receptor Interleukin-1 receptor accessory protein-like 1 IL1RAPL1 TIGIRR-2 at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction