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Sigma Aldrich Fine Chemicals Biosciences IL 4 human Animal componen
Supplier: Sigma Aldrich Fine Chemicals Biosciences SRP309320UG
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation survival and gene expression. Produced by mast cells T cells and bone marrow stromal cells IL-4 regulates the differentiation of naive CD4 T cells into helper Th2 cells characterized by their cytokine-secretion profile that includes secretion of IL-4 IL-5 IL-6 IL-10 and IL-13 which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.
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