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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA
Supplier: Genscript Corporation Z0313610
Interleukin-6 Receptor Alpha also known as IL-6RA IL-6R1 and CD126 belongs to the type I cytokine receptor family. It is mainly expressed on T cells fibroblasts and macrophages. IL-6RA couples with gp130 to form the IL-6 receptor; IL-6RA binds specifically to IL-6 and depends on gp130 to transmit signals. IL-6RA dysfunction has been correlated with the pathogenesis of many diseases such as multiple myeloma autoimmune diseases and prostate cancer. Soluble IL-6RA which consists of only the extracellular domain of IL-6RA acts as an agonist of IL-6 activity.
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