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ACROBiosystems Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (ILR-H525x) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Asp 239 (IL-7RA) & Gln 23 - Lys 231 (TSLPR) (Accession # P16871-1 (IL-7RA) & Q9HC73-1 (TSLPR)).
Supplier: ACROBiosystems ILRH525X100UG
TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.
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