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ABclonal Technology IL1B Rabbit mAb
SDP

Supplier:  ABclonal Technology A25874100UL

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This gene encodes a protein in the interleukin 1 cytokine family produced by activated macrophages as a proprotein and activated by caspase 1 (CASP1 ICE) This cytokine mediates the inflammatory response and is involved in cell proliferation differentiation and apoptosis It induces cyclooxygenase-2 (COX2) in the CNS contributing to inflammatory pain hypersensitivity and is implicated in osteoarthritis Elevated IL-1B levels are found in patients with severe COVID-19 where it plays a role in lung damage due to the inflammatory response triggered by SARS-CoV-2 This gene is part of a cytokine gene cluster on chromosome 2 which includes eight other interleukin 1 family genes

Catalog No. 50-000-09178


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