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Medchemexpress LLC Ilginatinib (NS-018) | 1239358-86-1 | 99.9% | 389.43 | 5 MG
SDP

Catalog No. 502082154
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Ilginatinib (NS-018) is a highly active, orally bioavailable JAK2 inhibitor (IC50 of 0.72 nM), showing high selectivity over JAK1, JAK3, and Tyk2. It also inhibits Src-family kinases and potently acts against cell lines with JAK2V617F, MPLW515L mutations, or TEL-JAK2 fusion genes. Ilginatinib suppresses CFU-GM formation from MDS-derived BMMNCs and STAT3 phosphorylation in MDS patients. In vivo, it improves survival and reduces disease-related symptoms in models.

  • Highly active and orally bioavailable JAK2 inhibitor
  • Selective for JAK2 over JAK1, JAK3, Tyk2
  • Inhibits Src-family kinases
  • Potent against specific mutated cell lines
  • Suppresses CFU-GM formation and STAT3 phosphorylation
  • Improves survival and reduces disease symptoms in vivo

Catalog No. 50-208-2154 Supplier Medchemexpress LLC Supplier No. HY19631A5MG
May include imposed supplier surcharges.
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Ilginatinib (NS-018) is a highly active, orally bioavailable JAK2 inhibitor (IC50 of 0.72 nM), showing high selectivity over JAK1, JAK3, and Tyk2. It also inhibits Src-family kinases and potently acts against cell lines with JAK2V617F, MPLW515L mutations, or TEL-JAK2 fusion genes. Ilginatinib suppresses CFU-GM formation from MDS-derived BMMNCs and STAT3 phosphorylation in MDS patients. In vivo, it improves survival and reduces disease-related symptoms in models.

  • Highly active and orally bioavailable JAK2 inhibitor
  • Selective for JAK2 over JAK1, JAK3, Tyk2
  • Inhibits Src-family kinases
  • Potent against specific mutated cell lines
  • Suppresses CFU-GM formation and STAT3 phosphorylation
  • Improves survival and reduces disease symptoms in vivo

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