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Cayman Chemical Ilorasertib 10MG
Supplier: Cayman Chemical 3420410 MG
A multi-kinase inhibitor; inhibits Aurora C, VEGFR1, VEGFR2, FLT3, CSF-1R, and Aurora B (IC50s = 1, 1, 2, 1, 3, and 7 nM, respectively); inhibits PDGFRα, PDGFRβ, c-Kit, VEGFR3, and Aurora A (IC50s = 11, 13, 20, 43, and 120 nM, respectively); inhibits autophosphorylation of Aurora A, -B, and -C in HeLa cells (IC50s = 189, 13, and 13 nM, respectively); inhibits proliferation of a variety of cancer cells, including MV4-11, SUP-B15, and H1299 cells (IC50s = 0.3, 4, and 2 nM, respectively); decreases histone H3 phosphorylation in blood-borne tumor cells in an engrafted mouse model of leukemia at 25 mg/kg and reduces tumor growth in a variety of mouse xenograft models
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