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Medchemexpress LLC Imatinib Mesylate | 220127-57-1 | 99.9% | C30H35N7O4S | 5 G
Supplier: Medchemexpress LLC HY509465G
Imatinib Mesylate is an orally active tyrosine kinase inhibitor that targets c-Kit, Bcr-Abl, and PDGFR (IC50 ≈ 100 nM). It is intended for research use only, serving as a laboratory chemical and for the manufacture of substances.
- Inhibits c-Kit autophosphorylation, MAPK, and Akt activation.
- Effective against Bcr-Abl, Kit, and PDGFR.
- Multi-target inhibitor for various Abl and Kit kinases.
- Does not inhibit Src family, c-Fms, Flt3, or EGFR kinases.
- Inhibits tyrosine phosphorylation and cell growth in specific cell lines.
- Demonstrates antileukemic activity in CML and Ph+ ALL.
- Reduces lung injury in rat ischemia/reperfusion injury models.
- Stable under recommended storage conditions.
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