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Apexbio Technology LLC Imatinib (STI571) 152459-95-5 100mg
Supplier: Apexbio Technology LLC B2171100
Imatinib (STI571) (CAS 152459-95-5) is a small-molecule inhibitor targeting protein tyrosine kinases including Abl kinase platelet-derived growth factor receptor (PDGFR) and c-Kit It modulates kinase activity by inhibiting phosphorylation thereby regulating oncogenic signal transduction pathways Imatinib exerts its biological activity primarily by suppressing the phosphorylation activity of Abl kinase (IC50 0 025 M) PDGFR (IC50 0 1 M) and c-Kit (IC50 0 1 M) In cell-based assays Imatinib inhibits PDGFR phosphorylation induced by PDGF-AA and PDGF-BB and reduces c-Kit-mediated signal transduction involved in tumor cell proliferation Based on these pharmacological properties Imatinib holds research potential in oncology for investigating kinase-driven cellular processes and therapeutic interventions
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