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Medchemexpress LLC Imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, hydrochloride (1:1) | 58579-51-4 | 99.3% | 100 MG
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Supplier:  Medchemexpress LLC HYB0523A100MG

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Anagrelide hydrochloride is a potent inhibitor of phosphodiesterase type III (PDE3) with an IC50 of 36 nM. This imidazoquinazoline derivative acts as an inhibitor of platelet aggregation. It inhibits bone marrow megakaryocytopoiesis, decreases gastrointestinal stromal tumor (GIST) cell proliferation, and promotes their apoptosis in vitro. Anagrelide hydrochloride is also a platelet-lowering agent with antithrombopoietic action.

  • Potently inhibits the development of marrow megakaryocytes (IC50=26 nM).
  • Inhibits megakaryocytic cell growth.
  • Induces a cytotoxic effect in GIST882 cell line (IC50=16 nM).
  • Inhibits or reduces tumor growth in GIST model mice.

Catalog No. 50-004-06004


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