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Cayman Chemical ImIdazole Keton ErastIn 10mg

Supplier: Cayman Chemical 2708810 MG
An inducer of ferroptosis; inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter; increases production of lipid ROS in SUDHL6 DLBCL cells in a concentration-dependent manner, as well as reduces GSH levels in these cells (IC50 = 34 nM); inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM); reduces tumor growth in an SUDHL6 mouse xenograft model at 23 and 40 mg/kg
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