Thermo Scientific™ ImmunoCAP™ Seed, Legume and Nut Allergens

Catalog No.	Quantity	Code	Common Name
14-528-410P	10 Tests	Rf347	Quinoa
14-411-501P	16 Tests	f14	Soybean
14-411-301P	16 Tests	f4	Wheat
14-412-601P	16 Tests	f13	Peanut
14-412-501P	16 Tests	f11	Buckwheat
14-412-401P	16 Tests	f8	Maize, Corn
14-412-301P	16 Tests	f5	Rye
14-417-201P	16 Tests	f6	Barley
14-417-301P	16 Tests	f7	Oat
14-417-601P	16 Tests	f12	Pea
14-417-401P	16 Tests	f9	Rice
14-417-501P	16 Tests	f10	Sesame seed
14-417-701P	16 Tests	f15	White bean
14-417-801P	16 Tests	f18	Brazil nut
14-417-901P	16 Tests	f20	Almond
14-421-201P	16 Tests	f36	Coconut
14-429-101P	10 Tests	f79	Gluten
14-445-901P	16 Tests	f55	Common millet
14-446-001P	16 Tests	f56	Foxtail millet
14-452-101P	16 Tests	f256	Walnut
14-452-801P	16 Tests	f17	Hazel nut
14-480-701P	10 Tests	f201	Pecan nut
14-481-501P	10 Tests	f235	Lentil
14-483-601P	10 Tests	f203	Pistachio
14-483-501P	10 Tests	f202	Cashew nut
14-484-301P	10 Tests	f299	Sweet chestnut
14-492-910P	10 Tests	Rf182	Lima bean
14-509-310P	10 Tests	Rf253	Pine nut, pignoles
14-509-710P	10 Tests	Rf224	Poppy seed
14-510-010P	10 Tests	Rf287	Red kidney bean
14-510-210P	10 Tests	Rf227	Sugar-beet seed
14-509-810P	10 Tests	Rf226	Pumpkin seed
14-518-710P	10 Tests	Rf305	Fenugreek
14-519-601P	10 Tests	f309	Chick pea
14-521-110P	10 Tests	Rf315	Green bean
14-521-310P	10 Tests	Rf316	Rape seed
14-525-010P	10 Tests	Rf333	Linseed
14-525-410P	10 Tests	Rf335	Lupin seed
14-528-210P	10 Tests	Rf345	Macadamia nut

Catalog No. 14-528-410P Supplier Thermo Scientific™ Supplier No. 14528410

Description

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Quantify specific IgE antibodies with ImmunoCAP™ Seed, Legume and Nut Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Scientific Name: Chenopodium quinoa
• Regulatory Status: ASR
• Code Type: Seed, Legume, and Nut
• Common Name: Quinoa
• Quantity: 10 Tests
• Code: Rf347