Thermo Scientific™ ImmunoCAP™ Tree Pollen Allergens

Catalog No.	Quantity	Code	Common Name
14-410-201P	16 Tests	t3	Common Silver Birch
14-411-801P	16 Tests	t17	Japanese Cedar
14-414-901P	16 Tests	t7	Oak
14-414-701P	16 Tests	t4	Hazel
14-414-801P	16 Tests	t5	American Beech
14-414-601P	16 Tests	t2	Grey Alder
14-415-001P	16 Tests	t9	Olive
14-415-101P	16 Tests	t12	Willow
14-416-101P	16 Tests	t1	Box Elder
14-422-501P	16 Tests	t6	Mountain Juniper
14-422-601P	16 Tests	t8	Elm
14-422-901P	16 Tests	t14	Cottonwood
14-422-701P	16 Tests	t10	Walnut
14-423-001P	16 Tests	t15	White Ash
14-423-201P	16 Tests	t18	Eucalyptus, Gum-tree
14-423-301P	16 Tests	t19	Acacia
14-423-101P	16 Tests	t16	White Pine
14-422-801P	16 Tests	t11	Maple Leaf Sycamore, London Plane
14-423-401P	16 Tests	t20	Mesquite
14-423-501P	16 Tests	t21	Melaleuca, Cajeput-tree
14-423-601P	16 Tests	t22	Pecan, Hickory
14-423-701P	16 Tests	t23	Italian/Mediterranean/Funeral Cypress
14-432-501P	10 Tests	t70	Mulberry
14-437-301P	10 Tests	t72	Queen Palm
14-437-401P	10 Tests	t73	Australian Pine
14-482-301P	10 Tests	t208	Linden
14-483-401P	10 Tests	t210	Privet
14-494-210P	10 Tests	Rt41	White Hickory
14-494-110P	10 Tests	Rt37	Bald Cypress
14-494-310P	10 Tests	Rt44	Hackberry
14-494-410P	10 Tests	Rt45	Cedar Elm
14-494-610P	10 Tests	Rt55	Scotch Broom
14-494-710P	10 Tests	Rt56	Bayberry
14-494-810P	10 Tests	Rt57	Red Cedar
14-494-910P	10 Tests	Rt71	Red Mulberry
14-500-210P	10 Tests	Rt205	Elder
14-500-510P	10 Tests	Rt201	Spruce
14-514-010P	10 Tests	Rt206	Chestnut
14-514-810P	10 Tests	Rt209	Horn Beam
14-515-510P	10 Tests	Rt211	Sweet Gum
14-516-710P	10 Tests	Rt217	Peppertree
14-518-501P	10 Tests	t212	Cedar
14-520-810P	10 Tests	Rt213	Pine
14-521-810P	10 Tests	Rt214	Date
14-525-210P	10 Tests	Rt218	Virgina Live Oak
14-530-901P	10 Tests	t222	Cypress

Catalog No. 14-410-201P Supplier Thermo Scientific™ Supplier No. 14410201

Description

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Quantify specific IgE antibodies with ImmunoCAP™ Tree Pollen Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Scientific Name: Betula verrucosa
• Regulatory Status: FDA Cleared
• Code Type: Tree
• Common Name: Common Silver Birch
• Quantity: 16 Tests
• Code: t3