Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Inauhzin 309271-94-1 10mg
Supplier: Apexbio Technology LLC B327210
Inauhzin (CAS 309271-94-1) is a small molecule inhibitor of SIRT1 exhibiting an IC50 of 0 7 2 M It selectively impedes SIRT1-mediated deacetylase activity in a dose-dependent manner leading to increased acetylation of histone H3 (at K382 and K9) and p53 Inauhzin does not significantly inhibit SIRT2 SIRT3 or HDAC8 in fluorescence-based assays Through activation of p53 Inauhzin induces apoptosis and suppresses proliferation in various human cancer cell lines with IC50 values ranging from 3 2 to 85 4 M depending on the cell type In xenograft models it promotes p53-dependent apoptosis highlighting its utility for studying SIRT1 inhibition and p53-mediated tumor suppression in oncology research
This item is not returnable.
View return policy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?