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Apexbio Technology LLC INCB28060 1029712-80-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A84485.1
INCB28060 (CAS 1029712-80-8) also known as Capmatinib or INC280 is an ATP-competitive inhibitor of the receptor tyrosine kinase c-Met (HGFR) This receptor plays essential roles in cellular processes including embryogenesis healing proliferation invasion and angiogenesis and is frequently overexpressed or mutated in cancers INCB28060 blocks c-Met phosphorylation and downstream signaling exhibiting an IC50 of 0 13 nM In preclinical studies it suppresses proliferation in cancer cell lines (e g SNU-5 S114) and inhibits migration in U-87MG and H441 cells In mouse tumor models oral administration reduces c-Met activation and tumor progression INCB28060 serves as a tool compound for investigating c-Met function in cancer research
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