This all-inclusive, cell-based assay system uses proprietary engineered cells expressing full-length, unmodified Human Mineralocorticoid Receptor (NR3C2). It includes a luciferase reporter gene linked to an MR-responsive promoter for quantifying MR activity, providing MR Reporter Cells, optimized media, Aldosterone, Luciferase Detection Reagent, and an assay plate.
- Utilizes engineered cells with full-length Human Mineralocorticoid Receptor (NR3C2, MR).
- Luciferase reporter gene linked to MR-responsive promoter for MR activity measurement.
- CryoMite™ process for high cell viability and immediate cell dispensing.
- Low background, high-sensitivity, and broad linear dynamic range.
- Stable light emission (5 to 90+ minutes) from luciferase detection reagent.
- Robust performance, suitable for high throughput screening (HTS) in a 3×32 assay, 96-well format.