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Apexbio Technology LLC Indirubin-3'-oxime 160807-49-8 5mg
Supplier: Apexbio Technology LLC B68655
Indirubin-3 -oxime (CAS 160807-49-8) is a derivative of indirubin investigated primarily as an inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 22 nM This compound also inhibits CDK5/p25 and CDK1/cyclin B with IC50 values of around 100 nM and 180 nM respectively while demonstrating weaker inhibitory activity against 5-lipoxygenase (IC50 7 8 10 M) Due to its modulation of multiple kinases involved in cell signaling Indirubin-3 -oxime is widely utilized in research on cellular signaling pathways and the molecular mechanisms underlying disease
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