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  7. Indirubin-3'-oxime, Tocris Bioscience™

Indirubin-3'-oxime, Tocris Bioscience™

Catalog No. 181350
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Catalog No. Quantity
18-135-0 50 mg
18-131-0 10 mg
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Catalog No. 18-135-0 Supplier R&D Systems Supplier No. 1813/50
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Description

GSK-3β inhibitor. Also inhibits other protein kinases

Inhibitor of GSK-3β (IC50 = 190 nM) and cyclin dependent kinases (cdks; IC50 values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.

Chemical Identifiers

CAS 160807-49-8
Molecular Formula C16H11N3O2
Molecular Weight (g/mol) 277.28
MDL Number MFCD02683594
InChI Key LDEWQRSYYHTQRA-UHFFFAOYSA-N
Synonym indirubin-3'-monoxime, indirubin-3'-oxime, indirubin-3-oxime, indirubin-3monoxime, indirubin-3'-monooxime, indirubin-3-monoxime, 3-3-hydroxyamino-1h-indol-2-yl indol-2-one, indirubin-3′-monoxime, z-1h,1'h-2,3' biindolylidene-3,2'-dione-3-oxime, 3-1,3-dihydro-3-hydroxyimino-2h-indol-2-ylidene-1,3-dihydro-2h-indol-2-one
PubChem CID 5326739
IUPAC Name 3-(hydroxyamino)-1H,2'H-[2,3'-biindol]-2'-one
SMILES ONC1=C(NC2=CC=CC=C12)C1=C2C=CC=CC2=NC1=O

Specifications

Quantity 50 mg
Formula Weight 277.28
Percent Purity >99%
Chemical Name or Material Indirubin-3'-oxime

Safety and Handling

Recommended Storage Store at Room Temperature
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