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Apexbio Technology LLC Indomethacin(Synonyms: Indocin, Indometacin, Indomethacine, Indocid, Indocine, Amuno, Chrono-Indocid, Elmetacin), 1g, CAS: 53-86-1.
Supplier: Apexbio Technology LLC A84491000
Indomethacin (CAS 53-86-1) is a nonsteroidal anti-inflammatory compound that inhibits cyclooxygenase enzymes Cox-1 and Cox-2 displaying preferential inhibition toward Cox-1 (IC50 230 nM) compared to Cox-2 (IC50 630 nM) Additionally it acts as an agonist of peroxisome proliferator-activated receptor gamma (PPAR ) a transcriptional regulator implicated in adipogenesis Indomethacin can also activate PPAR Furthermore studies indicate that indomethacin stabilizes cholesterol-rich nanoscale clusters enhancing membrane phase separation and potentially altering membrane-dependent signaling pathways This profile makes indomethacin useful for investigating inflammation-associated processes lipid metabolism and membrane signaling mechanisms
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