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STEMCELL Technologies Indomethacin, Size: 1 g
SDP

Supplier:  STEMCELL Technologies 73942

Encompass

Indomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.). Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 µM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.). DIFFERENTIATION· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.). · Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).CANCER RESEARCH · Inhibits growth of mouse mammary tumors (Fulton).· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).

Catalog No. 50-197-6153


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