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Apexbio Technology LLC Indoximod (NLG-8189) 110117-83-4 200mg
Supplier: Apexbio Technology LLC B4900200
Indoximod (NLG-8189 CAS 110117-83-4) is an orally bioavailable small molecule that targets the indoleamine 2 3-dioxygenase (IDO) pathway a key regulator of tryptophan metabolism involved in tumor-mediated immune suppression By blocking IDO activity indoximod reduces the expansion of regulatory T cells (Tregs Foxp3 /CD4 /CD25 ) thereby attenuating tumor-associated immune tolerance Preclinical studies have demonstrated that indoximod enhances adaptive immune responses to antigens and dendritic cell vaccines and its combination with chemotherapeutics such as docetaxel has shown increased toxicity without reaching a maximum tolerated dose at 2000 mg twice daily Indoximod serves as a valuable tool in investigating immunoregulatory mechanisms and immunotherapy strategies in cancer research
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