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Cayman Chemical Indoxyl Sulfate potassium sa
Supplier: Cayman Chemical 16926250 MG
A uremic toxin and metabolite of tryptophan; activates AhR in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay); inhibits OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells; increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells at 0.2 and 1 mM; increases serum creatinine and BUN levels in the 5/6 nephrectomized rat model of chronic renal failure at 50 mg/kg
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