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AdipoGen INDY (5 mg)
SDP

Supplier:  AdipoGen AGCR13665M005

Encompass_Preferred

Chemical. CAS: 1169755-45-6. Formula: C12H13NO2S. MW: 235.3. Synthetic. Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme. Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same concentration). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells. Shown to induce regeneration and expansion of rat and adult human beta-cells in vivo or ex vivo.

Catalog No. 50-205-4046


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