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Abcam INDY, DYRK1A/B inhibitor, 5MG

Supplier:  Abcam AB2238905MG

Encompass_Preferred

MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.

The product is subject to the following: Abcam Restricted Use Statement

Catalog No. 50-270-2877


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