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Enzo Life Sciences Ingenol 3,20-dibenzoate (1mg). CAS: 59086-90-7
Supplier: Enzo Life Sciences BMLPE1860001
Ingenol is a diterpenoid related to phorbol. Activates protein kinase C (PKC) and competes with [3H]phorbol dibutyrate for binding to PKCα (Ki for binding=240 nM). Induces apoptosis. Anticancer agent. Shows potent antileukemic activity in the P388 mouse assay. Displays unusually high mouse ear inflammatory activity, even though the 20-hydroxy group is blocked with a benzoate ester. It appears likely that this high potency is due to metabolic cleavage of the 20-benzoate group, which releases the more potent ingenol 3-benzoate. Alternative name: IDB. Purity: ≥97%. Solubility: Soluble in DMSO (20mg/ml) or ethanol (20mg/ml). Long Term Storage: -20°C.
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