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STEMCELL Technologies L-Buthionine-(S,R)-sulfoximine, Size: 250 mg
Supplier: STEMCELL Technologies 1000560
L-Buthionine-(S,R)-sulfoximine is a potent and irreversible inhibitor of γ-glutamylcysteine synthetase (γGCS; Ki < 100 μM) and used to deplete glutathione and sensitize cells to anticancer agents (Griffith; Hibi et al.; Lewis-Wambi et al.; Marengo et al.). γGCS is a rate-limiting enzyme in the glutathione (GSH) biosynthetic pathway and essential for glutathione homeostasis and cell survival (Hibi et al.). CANCER RESEARCH· Decreases glutathione levels and elevates reactive oxygen species production, leading to apoptosis in neuroblastomas (Marengo et al.).· Predisposes estrogen-independent human breast cancer cells to estradiol-induced apoptosis (Lewis-Wambi et al.).
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WARNING: Cancer - www.P65Warnings.ca.gov
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