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Medchemexpress LLC Ino-1001 | 501364-82-5 | C23H25N3O4S | 50 MG
Supplier: Medchemexpress LLC HY1504550MG
INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. It acts as a potent enhancer of radiation sensitivity, augmenting radiation-induced cell killing by interfering with DNA repair mechanisms, which leads to necrotic cell death. INO-1001 has demonstrated anti-tumor effects.
- Potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor.
- Enhances radiation sensitivity.
- Augments radiation-induced cell killing.
- Interferes with DNA repair mechanisms.
- Leads to necrotic cell death.
- Exhibits anti-tumor effects.
- Inhibits PARP at 0.05 μM in Chinese hamster ovary AA8 (CHO) cells.
- ED50 of 1 μM for inhibition of PARP1 in CHO-K1 cells.
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